Relationship between apolipoprotein AI gene rs12721026 polymorphism and cerebral hemorrhage / 中华神经医学杂志

ABSTRACT

Objective To study the relationship between apolipoprotein AI (ApoAI) gene rs12721026 polymorphism and cerebral hemorrhage.Methods One hundred and eighty patents with cerebral hemorrhage,admitted to our hospital from May 2014 to June 2015,were enrolled as ICH group,and 100 normal subjects were chosen as control group.ApoAI gene polymorphisms and related serum lipid parameters of the patients between the two groups were compared.Results The frequency of ApoA I gene polymorphism rs 12721026 alleles G and T in the ICH group showed no significant difference as compared with that in the control group (P＞0.05).The total cholesterol (TC) and triglyceride (TG) levels in the ICH group were significantly higher than those in the control group (P＜0.05),and high density lipoprotein cholesterol (HDL-C) level in the ICH group was significantly lower than that in the control group (P＜0.05);There was no statistically significant difference on the low density lipoprotein cholesterol (LDL-C),ApoAI and lipopolysaccharide (Lp) levels between the ICH group and control group (P＞0.05).In the ICH group,the TC,TG,LDL-C,ApoAI and Lp levels showed no significant difference between TT and GG/TG rs12721026 genotypes (P＞0.05);HDL-C level ofTT genotype was significantly lower than that of GG/TG genotype (P＜0.05).Conclusion ApoAI gene rs12721026 polymorphism shows no obvious role in the pathogenesis of cerebral hemorrhage,but may be associated with reduced HDL-C level.