Living donor liver transplantation for patients with alcoholic liver disease
Korean Journal of Hepato-Biliary-Pancreatic Surgery
; : 14-20, 2013.
Article
em En
| WPRIM
| ID: wpr-103777
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUNDS/AIMS: Since most transplantation studies for alcoholic liver disease (ALD) were performed on deceased donor liver transplantation, little was known following living donor liver transplantation (LDLT). METHODS: The clinical outcome of 18 ALD patients who underwent LDLT from Febraury 1997 to December 2004 in a large-volume liver transplantation center was assessed retrospectively. RESULTS: The model for end-stage liver disease score was 23+/-11, and mean pretransplant abstinence period was 16+/-13 months, with 14 (77.8%) patients being abstinent for at least 6 months. Graft types were right lobe grafts in 11, left lobe grafts in 2 and dual grafts in 5. Graft to recipient body weight ratio was 0.94+/-0.16. The relapse rates in patients who did and did not maintain 6 months of abstinence were 7.1% and 50%, respectively (p=0.097). Younger recipient age was a significant risk factor for alcohol relapse (p=0.027). Five recipients with antibody to hepatitis B surface antigen (HBsAg) received core antibody-positive liver graft, but two of them showed positive HBsAg seroconversion. Overall 5-year patient survival rate following LDLT was 87.8%, with a 5-year relapse rate of 16.7%. CONCLUSIONS: Pretransplant abstinence for 6 months appears to be benefical for preventing posttransplant relapse. Life-long prophylactic measure should be followed after use of anti-HBc-positive liver grafts regardless of hepatitis B viral marker status of the recipient.
Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Recidiva
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Doadores de Tecidos
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Peso Corporal
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Biomarcadores
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Taxa de Sobrevida
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Fatores de Risco
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Transplante de Fígado
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Doadores Vivos
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Transplantes
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Alcoólicos
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Ano de publicação:
2013
Tipo de documento:
Article