Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report
Korean Journal of Pathology
; : 111-114, 2011.
Article
em En
| WPRIM
| ID: wpr-104146
Biblioteca responsável:
WPRO
ABSTRACT
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fosfotransferases
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Recidiva
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Baço
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Esplenectomia
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Seguimentos
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Actinas
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Colágeno
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Receptores Proteína Tirosina Quinases
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Molécula-1 de Adesão Celular Endotelial a Plaquetas
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Fibroblastos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Korean Journal of Pathology
Ano de publicação:
2011
Tipo de documento:
Article