Reward Learning in Euthymic Patients with Bipolar Disorder Using a Probabilistic Reward Task / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 28-35, 2012.
Article
em Ko
| WPRIM
| ID: wpr-106957
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Bipolar disorder patients often show excessive goal-directed and pleasure-seeking behavior during manic episodes and reduced hedonic capacity during depressive episodes, indicating that bipolar disorder might involve altered reward processing. As such, bipolar disorder subjects have been reported to show impaired reward learning in situations requiring integration of reinforcements over time. In this study, we examined characteristics of reward learning in euthymic patients with bipolar disorder using a probabilistic reward task.METHODS:
We recruited 23 euthymic patients with bipolar disorder and 47 healthy subjects for the probabilistic reward task. This task is a reward-based paradigm to produce a response bias, in which correct identifications of two ambiguous stimuli are differently rewarded. The other dependent measures were the discriminability, hit rate and reaction time.RESULTS:
Relative to comparison subjects, bipolar patients showed a reduced acquisition of response bias toward the more frequently rewarded stimulus (p<0.01). The overall reward learning was positively correlated with state and trait anxiety levels in bipolar patients (p<0.01). No significant differences of discriminability, hit rates, and reaction time were found between bipolar patients and controls.CONCLUSION:
These findings suggest that euthymic patients with bipolar disorder may have deficits in reward learning related to anxiety.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Ansiedade
/
Tempo de Reação
/
Reforço Psicológico
/
Recompensa
/
Transtorno Bipolar
/
Viés
/
Aprendizagem
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2012
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
COREIA DO SUL
/
KR
/
SOUTH KOREA