The Expression of Vascular Endothelial Growth Factor (VEGF)-C and VEGF-D in Early Gastric Cancer That's Invaded the Submucosa
Journal of the Korean Surgical Society
; : 48-53, 2008.
Article
em Ko
| WPRIM
| ID: wpr-113678
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Vascular endothelial growth factor (VEGF)-C and VEGF-D are considered novel growth factors that potentially induce lymphangiogenesis and hyperplasia of lymphatic vessels. The aim of this study was to investigate whether the expressions of VEGF-C and VEGF-D are associated with the clinicophathologic factors, and particularly lymphatic invasion and lymph node metastasis, in early gastric cancers that's invaded the submucosa. METHODS: Using immunohistochemical staining, we studied the VEGF-C and VEGF-D expressions in the gastric cancer specimens from 83 patients who underwent curative gastrectomy. RESULTS: The VEGF-C and VEGF-D immunoreactivity was mainly located in the cytoplasm of the tumor cells. There was a positive VEGF-C expression in 27 of 83 cases (32.5%). The VEGF-D positivity rate was lower than the VEGF-C positivity rate. VEGF-D was positive in 20 of 83 cases (24.0%). A VEGF-C positive expression was associated with lymphatic invasion (P=0.018) and lymph node metastasis (P=0.001). However, the expression of VEGF-D had no correlation with any of the clinicopathologic factors, including lymphatic invasion and lymph node metastasis. CONCLUSION: The VEGF-C expression may have a role in lymph node metastasis of gastric cancer cells. The VEGF-C expression in tumor specimens may be a reliable marker for lymph node metastasis of early gastric cancer that's invaded the submucosa.
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Base de dados:
WPRIM
Assunto principal:
Neoplasias Gástricas
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Citoplasma
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Peptídeos e Proteínas de Sinalização Intercelular
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Vasos Linfáticos
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Fator A de Crescimento do Endotélio Vascular
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Fator C de Crescimento do Endotélio Vascular
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Fator D de Crescimento do Endotélio Vascular
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Linfangiogênese
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Hiperplasia
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Linfonodos
Limite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Surgical Society
Ano de publicação:
2008
Tipo de documento:
Article