E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 349-354, 2011.
Article
em Ko
| WPRIM
| ID: wpr-116310
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC. METHODS: Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008. RESULTS: The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients. CONCLUSION: The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fumaça
/
Adenocarcinoma
/
Fumar
/
Proteínas Oncogênicas Virais
/
Prevalência
/
Fatores de Risco
/
Carcinoma Pulmonar de Células não Pequenas
/
Corantes
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
Ko
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2011
Tipo de documento:
Article