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The Change of Cytokines by Risperidone in Patients with Schizophrenia / 신경정신의학
Article em Ko | WPRIM | ID: wpr-117545
Biblioteca responsável: WPRO
ABSTRACT
OBJECT This study was carried out to evaluate immunologic difference between baseline and after 4 weeks drug treatment with atypical antipsychotics (rispreidone) by measurement of serum concentration of 6 cytokines.

METHODS:

The subjets were composed of 25 patients who are admitted at Dajeon St's Marys hospital of psychiatry department and diagnosed as schizophrenia by DSM-IV diagnositc criteria. We measured serum IL-1beta, IL-2, IL-6, IL-12, INF-gamma, TNF-alpha concenatrations by quantitative ELISA method using ELISA kit (Endogen Inc., Woburn, MA, USA).The two psyciatrists performed PANSS examination between baseline and after 4 weeks risperidone treatments.

RESULTS:

The serum level of IL-12 was increased significantly after medication of 4 weeks and the serum concentration of IFN-gamma showed the tendency of decreasement but not significant. The serum level of the other cytokines showed no significant change.

CONCLUSIONS:

We spectulate that the increasement of IL-12 may contribute to role of activation of immune response by treatment of antipsychotic medication (risperidone). This study is first trial of IL-12 study in neuropsychiatric field and IL-12 which play important role of immune response becomes interesting subjects in immune research.
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Texto completo: 1 Base de dados: WPRIM Assunto principal: Esquizofrenia / Antipsicóticos / Ensaio de Imunoadsorção Enzimática / Citocinas / Interleucinas / Interleucina-6 / Interleucina-2 / Fator de Necrose Tumoral alfa / Interleucina-12 / Risperidona Limite: Humans Idioma: Ko Revista: Journal of Korean Neuropsychiatric Association Ano de publicação: 2000 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Esquizofrenia / Antipsicóticos / Ensaio de Imunoadsorção Enzimática / Citocinas / Interleucinas / Interleucina-6 / Interleucina-2 / Fator de Necrose Tumoral alfa / Interleucina-12 / Risperidona Limite: Humans Idioma: Ko Revista: Journal of Korean Neuropsychiatric Association Ano de publicação: 2000 Tipo de documento: Article