Predictive factors of restenosis after successful percutaneous transluminal coronary angioplasty / 대한내과학회지
Korean Journal of Medicine
; : 684-694, 1998.
Article
em Ko
| WPRIM
| ID: wpr-121587
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Restenosis after successful PTCA remains the main limitation of this technique. Restenosis is a response to injury of the vessel wall, platelet aggregation, thrombus formation, liberation of growth factors, cellular hyperplasia involving predominantly smooth muscle proliferation and migration, and intercellular matrix formation. The identification of risk factors for restenosis could help to prevent and reduce the impact of this phenomenon. We undertook this study to evaluate retrospectively the association between risk factors and restenosis after PTCAMETHODS:
We studied 123 patients and 174 lesions that underwent successful PTCA and the follow-up period (from PTCA to follow-up angiography) was 8.2+/-5.8 months in all patients. They were divided into two groups according to the restenosis. Clinical feature, lesional feature, PTCA procedural feature, and other risk factors were compared. Restenosis was defined as the cutoff point of >50% in diameter stenosis at angiographic follow-up.RESULTS:
1) Restenosis was found in 68 lesions after successful PTCA(39.1%). 2) Clinical features of restenosis group are similar to no restenosis group 3) Thrombus (p=0.002), total occlusion(p=0.001), severity of stenosis in the initial lesion(p=0.013) and residual stenosis(p=0.001) were found to be independently associated with restenosis, whereas other lesional characteristics were not. 4) Balloon inflation duration(p=0.017) and dissection(p=0.002) were found to be independently associated with restenosis, whereas other procedural characteristics were not.CONCLUSION:
Thrombus, total occlusion, dissection, severity of stenosis in the initial lesion, balloon inflation time, residual stenosis were found to be associated with restenosis after PTCA in our study.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Trombose
/
Angioplastia Coronária com Balão
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Agregação Plaquetária
/
Estudos Retrospectivos
/
Fatores de Risco
/
Seguimentos
/
Constrição Patológica
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Hiperplasia
/
Inflação
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Medicine
Ano de publicação:
1998
Tipo de documento:
Article