Report of 3 Cases of Chronic Myelogenous Leukemia with Thrombocythemic Onset / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 159-162, 2002.
Article
em Ko
| WPRIM
| ID: wpr-121987
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Differential diagnosis may be difficult between essential thrombocythemia (ET) and chronic myelogenous leukemia (CML) with marked thrombocytosis, mild leukocytosis, and a few immature myeloid cells in peripheral blood at onset. The aim of the present study was to analyze clinical, hematologic, and molecular features of patients with CML, mimicking ET. METHODS: Among patients from Ewha and Gachon Gil Medical Center between January 1990 and June 2001, our study group included 3 patients with Ph-positive CML with marked thrombocy-tosis (>600 X 10(9)/L) and mild leukocytosis (<20 X 10(9)/L) and 12 patients of the typical ET as a con-trol group. RESULTS: Peripheral blood basophilia (4 - 12%) and a few immature granulocytes (1 - 9%) were the characteristic features of CML with thrombocythemic onset, compared with the typical ET. There was no evidence of bone marrow eosinophilia, basophilia, or fibrosis in CML with thrombocythemic onset. CONCLUSIONS: Our study suggests that peripheral basophilia as well as the positivity of Ph chromo-somes or bcr/abl gene rearrangement can be a clue to diagnosis of CML.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Trombocitose
/
Medula Óssea
/
Fibrose
/
Rearranjo Gênico
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Células Mieloides
/
Diagnóstico
/
Diagnóstico Diferencial
/
Eosinofilia
/
Granulócitos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2002
Tipo de documento:
Article