The Frequency of Serum Autoantibodies to the Epidermal Antigens among Normal Elderly People / 대한피부과학회지
Korean Journal of Dermatology
; : 402-406, 2001.
Article
em Ko
| WPRIM
| ID: wpr-130010
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
One of the age-associated changes in immunity is the increase of autoantibodies due to dysregulation of the immune function. Anti-basement membrane zone antibodies were also reported to be found in the sera taken from normal elderly people.OBJECTIVE:
The purpose of this study is to examine the frequency of autoantibodies to the epidermal antigens in the sera among normal elderly people.METHODS:
Indirect immunofluorescence using salt-split human skin and immunoblotting with extracts from epidermoid carcinoma cell line(A431) were performed using sera from forty elderly persons without any systemic disease.RESULTS:
Among 40 elderly individuals, 3 cases(7.5%) were positive for anti-basement membrane zone IgG antibodies in indirect immunofluorescence, and the titers were 110 to 140 dilution factor. In immunoblottings, 4 cases(10%) were positive with epidermal antigens; 2 were positive against the 180kD protein with IgG and IgA autoantibodies, 1 showed positive bands at 230kD and 180kD antigens with IgG, and remaining one showed positive at 130kD antigen who had negative result in indirect immunofluorescence.CONCLUSION:
Autoantibodies against epidermal antigens(bullous pemphigoid angigen[230/180kD] or pemphigus vulgaris antigen[130kD]) can be detected without any bullous cutaneous diseases among elderly people; possibly as an epiphenomenon of immunosenescence.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pele
/
Autoanticorpos
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Imunoglobulina A
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Imunoglobulina G
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Carcinoma de Células Escamosas
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Immunoblotting
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Imunofluorescência
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Penfigoide Bolhoso
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Pênfigo
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Técnica Indireta de Fluorescência para Anticorpo
Limite:
Aged
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Dermatology
Ano de publicação:
2001
Tipo de documento:
Article