Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time
Annals of Laboratory Medicine
; : 339-344, 2012.
Article
em En
| WPRIM
| ID: wpr-132343
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Major burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of pro-inflammatory and anti-inflammatory cytokines following burn injury and determined the relationship between these levels and burn size in adult Korean patients with burn injury. METHODS: Blood samples from 9 healthy controls and 60 Korean burn patients were collected on days 1, 3, 7, 14, and 21 after burn injury, and concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, and granulocyte-colony stimulating factor (G-CSF) were measured. Burn patients were divided into 3 groups according to burn size (15-30%, 31-50%, >50% total body surface area), and the concentrations of the cytokines were compared between these groups and the control group over 3 weeks. RESULTS: Compared to their levels in controls, IL-6, IL-8, IL-10, TNF-alpha, and G-CSF levels in burn patients were significantly higher during the observation period. Median concentrations of IL-8, IL-10, and G-CSF at each time point increased with burn size, although peak levels and time to peak levels of these cytokines differed from patient to patient. CONCLUSIONS: These findings indicate that IL-6, IL-8, IL-10, TNF-alpha, and G-CSF are important mediators in inflammatory changes after burn injury; however, various factors, including burn size, may influence the concentrations of these cytokines.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fatores de Tempo
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Queimaduras
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Fator Estimulador de Colônias de Granulócitos
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Interleucina-8
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Interleucina-10
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Povo Asiático
/
República da Coreia
Limite:
Adolescent
/
Adult
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Aged
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Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2012
Tipo de documento:
Article