Prognosis of Recurrence after Complete Resection in Early-Stage Non-Small Cell Lung Cancer
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 449-456, 2013.
Article
em En
| WPRIM
| ID: wpr-13272
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Tumor recurrence is the most common cause of treatment failure, even after complete resection of early-stage non-small cell lung cancer (NSCLC). In this study, we investigated the prognosis of patients with early recurrence in order to identify independent risk factors related to early recurrence. METHODS: Between February 1995 and December 2012, 242 patients who underwent surgical resection for stage I NSCLC at Dong-A University Hospital were reviewed. The factors predicting overall survival (OS) and early recurrence were investigated. We also investigated the relationship between the patterns and period of recurrence and clinicopathological factors. RESULTS: For patients with stage IA and IB NSCLC, the 5-year OS rate was 75.7% and 57.3% (p=0.006), respectively. A multivariate Cox proportional hazards model demonstrated that gender (p=0.004), comorbidity number (p=0.038), resection type (p=0.002), and tumor size (p=0.022) were the statistically significant predictors of OS. Moreover, the multivariate analysis revealed that smoking history (p=0.023) and histologic grade (p=0.012) were the independent predictors of early recurrence. Additionally, only histologic grade (poor differentiation) was found to be significantly associated with a higher frequency of distant metastasis; there was no relationship between the patterns and period of recurrence and clinicopathological factors. CONCLUSION: The present study demonstrated that smoking history and histologic grade were independent prognostic factors for early recurrence within two years in patients with early-stage NSCLC. Patients with these predictive factors may be good candidates for adjuvant therapy.
Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Prognóstico
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Recidiva
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Fumaça
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Fumar
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Comorbidade
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Modelos de Riscos Proporcionais
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Análise Multivariada
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Fatores de Risco
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Falha de Tratamento
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Carcinoma Pulmonar de Células não Pequenas
Tipo de estudo:
Etiology_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2013
Tipo de documento:
Article