Predictive value of sperm motility characteristics assessed by computer-assisted sperm analysis in intrauterine insemination with superovulation in couples with unexplained infertility / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 47-52, 2011.
Article
em En
| WPRIM
| ID: wpr-133469
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To determine whether characteristics of sperm motility obtained by computer-assisted sperm analysis (CASA) could predict pregnancy after intrauterine insemination (IUI) in couples with unexplained infertility. METHODS: Three hundred eighty-three cycles of intrauterine insemination with superovulation were retrospectively analyzed. Semen analysis was performed with CASA before and after swim-up and the parameters were compared between pregnant and non-pregnant women. RESULTS: The pregnancy rate per cycle was 14.1%. Pregnant and non-pregnant women were comparable in terms of age, infertility duration, the number of dominant follicles. While sperm concentration, motility, and parameters such as average path velocity (VAP) and percentage rapid (RAPID) before semen preparation were significantly different between the pregnancy and non-pregnancy groups, there were no differences in sperm parameters when comparing the two groups after preparation. Using a receiver operating characteristic curve to measure sensitivity and specificity, the optimal threshold value for the predictors of pregnancy was revealed to be a concentration of > or =111x10(6)/mL, a motility of > or =51.4%, and RAPID > or =30.1% before preparation for IUI. CONCLUSION: Sperm parameters including concentration, motility, and RAPID before sperm preparation could have predictive value for pregnancy outcome after intrauterine insemination with superovulation in couples with unexplained infertility, and would be helpful when counseling patients before they make the decision to proceed with IVF/ICSI-ET.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sêmen
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Motilidade dos Espermatozoides
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Espermatozoides
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Superovulação
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Processamento de Imagem Assistida por Computador
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Resultado da Gravidez
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Inseminação Artificial
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Características da Família
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Estudos Retrospectivos
/
Curva ROC
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Clinical and Experimental Reproductive Medicine
Ano de publicação:
2011
Tipo de documento:
Article