A case of membranous nephropathy as a manifestation of graft-versus-host disease
Kidney Research and Clinical Practice
; : 39-42, 2013.
Article
em En
| WPRIM
| ID: wpr-142106
Biblioteca responsável:
WPRO
ABSTRACT
Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human leukocyte antigen-identical brother following myeloablative conditioning chemotherapy. NS occurred 21 months after HSCT without any concurrent features of chronic GVHD. The patient was treated with prednisolone and cyclosporine after renal biopsy confirmed membranous nephropathy, and achieved complete remission. Our report contradicts previous assumptions that concomitant chronic GVHD is responsible for the development of NS, suggesting that NS can develop as a new, independent manifestation of GVHD.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Biópsia
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Prednisolona
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Glomerulonefrite Membranosa
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Ciclosporina
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Transplante de Células-Tronco Hematopoéticas
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Irmãos
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Doença Enxerto-Hospedeiro
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Anemia Aplástica
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Leucócitos
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Síndrome Nefrótica
Limite:
Female
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Humans
Idioma:
En
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2013
Tipo de documento:
Article