The Relationship between Magnesium and Endothelial Function in End-Stage Renal Disease Patients on Hemodialysis
Yonsei Medical Journal
; : 1446-1453, 2016.
Article
em En
| WPRIM
| ID: wpr-143175
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Chronic kidney disease (CKD) patients tend to have higher serum magnesium values than healthy population due to their positive balance of magnesium in kidney. Recent studies found that magnesium level is positively correlated with endothelial function. Therefore, this study was conducted to define the relationship between magnesium level and endothelial dysfunction in end stage renal disease (ESRD) patients on hemodialysis (HD). MATERIALS ANDMETHODS:
A total of 27 patients were included in this cross-sectional study. Iontophoresis with laser-Doppler flowmetry, flow mediated dilation (FMD), and carotid intima-media thickness were measured. Patients' average serum magnesium levels were measured over previous three months, including the examination month. Pearson's correlation coefficient analysis and multivariate regression model were used to define the association between magnesium and endothelial function.RESULTS:
In the univariate analysis, higher magnesium levels were associated with better endothelium-dependent vasodilation (EDV) of the FMD in ESRD patients on HD (r=0.516, p=0.007). When the participants were divided into two groups according to the median magnesium level (3.47 mg/dL), there was a significant difference in EDV of FMD (less than 3.47 mg/dL, 2.8±1.7%; more than 3.47 mg/dL, 5.1±2.0%, p=0.004). In multivariate analysis, magnesium and albumin were identified as independent factors for FMD (β=1.794, p=0.030 for serum magnesium; β=3.642, p=0.012 for albumin).CONCLUSION:
This study demonstrated that higher serum magnesium level may be associated with better endothelial function in ESRD patients on HD. In the future, a large, prospective study is needed to elucidate optimal range of serum magnesium levels in ESRD on HD patients.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vasodilatação
/
Iontoforese
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Estudos Transversais
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Análise Multivariada
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Estudos Prospectivos
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Diálise Renal
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Fluxometria por Laser-Doppler
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Endotélio
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Insuficiência Renal Crônica
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Espessura Intima-Media Carotídea
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2016
Tipo de documento:
Article