MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
Experimental & Molecular Medicine
; : e156-2015.
Article
em En
| WPRIM
| ID: wpr-147138
Biblioteca responsável:
WPRO
ABSTRACT
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappaB function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappaB pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Transdução de Sinais
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Linhagem Celular
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Lipopolissacarídeos
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NF-kappa B
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Interleucina-6
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Espécies Reativas de Oxigênio
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Receptores do Leucotrieno B4
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Macrófagos Peritoneais
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Leucotrieno B4
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Fator 88 de Diferenciação Mieloide
Limite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2015
Tipo de documento:
Article