FOXP3+T Cells and TGF-beta1 in Colonic Mucosa of Children with Crohn's Disease / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition
; : 258-268, 2011.
Article
em Ko
| WPRIM
| ID: wpr-148025
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Forkhead box protein 3 (FOXP3)+T cells are the major regulatory T cells controlling all aspects of the immune response. Transforming growth factor-beta (TGF-beta) is a suppressive cytokine which mediates the suppressive action of FOXP3+T cells. The aim of this study was to investigate the role of FOXP3+T cells, TGF-beta in colonic mucosa of children with Crohn's disease (CD).METHODS:
Colonic mucosal biopsies were obtained from 10 children with CD (12~15 years of age) and 11 control (8~15 years of age). Frequencies of FOXP3+T, CD4+T cells and TGF-beta1 expression were examined in the lamina propria (LP) and lymphoid aggregates or follicles (LA/F) by immunohistochemistry, and later evaluated by association with disease activity.RESULTS:
In the LP of CD group, frequencies of FOXP3+T, CD4+T cells, proportion of FOXP3/CD4+T cells and TGF-beta1 expression significantly increased compared to the control. In the LA/F of CD group, frequency of FOXP3+T cells, proportion of FOXP3/CD4+T cells and TGF-beta1 expression significantly increased compared to the control (p<0.05). CD4+T cells also increased compared to the control, but this finding was not significant. In the LP and LA/F of CD group, frequency of FOXP3+T cells exhibited positive correlation with CD4+T cells (p<0.05). In the LP and LA/F of CD group, TGF-beta1 expression had positive correlation with CRP, Pediatric Crohn's Disease Activity Index, and negative correlation with hematocrit and albumin (p<0.05).CONCLUSION:
Increased frequency of FOXP3+T cells and TGF-beta1 expression in colonic mucosa of CD can be interpreted as a compensatory increase towards achieving down-regulation of immune responses.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Biópsia
/
Imuno-Histoquímica
/
Linfócitos T
/
Doença de Crohn
/
Regulação para Baixo
/
Fator de Crescimento Transformador beta
/
Linfócitos T Reguladores
/
Colo
/
Fator de Crescimento Transformador beta1
/
Hematócrito
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pediatric Gastroenterology and Nutrition
Ano de publicação:
2011
Tipo de documento:
Article