Pregnancy Outcome in Renal Transplant Recipients: A Retrospective Study / 대한주산의학회잡지
Korean Journal of Perinatology
; : 405-412, 2006.
Article
em Ko
| WPRIM
| ID: wpr-148659
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
The aim of our study was to identify graft, obstetric and maternal outcomes of pregnancies in renal transplant recipients at our center.METHODS:
A 14-year retrospective study between January 1990 and December 2003, 224 women 15 to 45 years of age had transplantation and were analyzed the outcomes of pregnancies, obstetric complications and graft function.RESULTS:
Thirty-four pregnancies occurred in 21 of 224 patients. The mean age at the time of conception was 29.5 years (21 to 36 years) with a mean interval of 61.9 months (one to 162 months). In the pregnancy outcome, there were the 23 live births (67.6%) included 13 preterm and 10 term deliveries, 3 spontaneous abortions (8.8%), 7 artificial abortions (20.5%) and one case of ectopic pregnancy (2.9%). Obstetric complications were; preeclampsia (39.1%), preterm labor (43.4%), urinary tract infections (38.2%) and gestational diabetes (8.6%). Nine pregnancies within 2 years of transplantation had the permissible obstetric outcomes comparing with the others after 2 years (spontaneous abortion p=0.77, artificial abortion p=0.88, live birth p=0.36). In twelve pregnancies appearing renal dysfunction associated with pregnancy, the abortion rate was increased comparing the others with stable renal function (p=0.006). Pre-pregnancy serum creatinine > or =1.4 mg/dl was associated with increased preterm delivery, but not significant (50.0% vs 28.5%, p=0.30). In graft function, serum creatinine 3~6 postpartum was significantly increased comparing pre-pregnancy levels (p=0.04). Five cases of 7 patients with acute rejection episode associated with pregnancy conceived after 4 years of transplantation. Two-year graft survival after delivery was 95.2% (20/21) and chronic rejection and graft failure was diagnosed in one case at postpartum 14 months.CONCLUSION:
These findings suggest that, if the graft function is stable, pregnancy within 2 years after renal transplantation might be safe. Pregnancy does not appear to have adverse effects on long term graft survival.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pré-Eclâmpsia
/
Gravidez Ectópica
/
Transplante
/
Infecções Urinárias
/
Resultado da Gravidez
/
Aborto Espontâneo
/
Estudos Retrospectivos
/
Transplante de Rim
/
Aborto Induzido
/
Diabetes Gestacional
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
Ko
Revista:
Korean Journal of Perinatology
Ano de publicação:
2006
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
COREIA DO SUL
/
KR
/
SOUTH KOREA