Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease
Endocrinology and Metabolism
; : 105-109, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-150111
Biblioteca responsável:
WPRO
ABSTRACT
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Diarreia
/
Doenças Negligenciadas
/
Infecções Diarreicas
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Doenças do Sistema Endócrino
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Outras Doenças Sanguíneas
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ásia
/
Recidiva
/
Testes Sorológicos
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Redução de Peso
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Doença Celíaca
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Doença de Graves
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Prevalência
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Genes MHC da Classe II
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Predisposição Genética para Doença
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Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
/
Europa
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo