Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
Experimental & Molecular Medicine
; : e353-2017.
Article
em En
| WPRIM
| ID: wpr-153369
Biblioteca responsável:
WPRO
ABSTRACT
Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called ‘beige fat’ (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Triglicerídeos
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Tecido Adiposo Marrom
/
Tecido Adiposo
/
Adipócitos
/
Corpo Humano
/
Metabolismo Energético
/
Tecido Adiposo Branco
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Temperatura Alta
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Homeostase
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Doenças Metabólicas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2017
Tipo de documento:
Article