Chemotherapeutic Candidate Inducing Immunological Death of Human Tumor Cell Lines
Immune Network
; : 66-69, 2012.
Article
em En
| WPRIM
| ID: wpr-154682
Biblioteca responsável:
WPRO
ABSTRACT
The immunological death induction by EY-6 on the human tumor cell lines was screened. Human colon carcinoma (HCT15, HCT116), gastric carcinoma (MKN74, SNU668), and myeloma (KMS20, KMS26, KMS34) cells were died by EY-6 treatment with dose-dependent manner. CRT expression, a typical marker for the immunological death, was increased on the EY-6-treated colorectal and gastric cancer cells. Interestingly, the effects on the myeloma cell lines were complicated showing cell line dependent differential modulation. Cytokine secretion from the EY-6 treated tumor cells were dose and cell-dependent. IFN-gamma and IL-12 secretion was increased in the treated cells (200% to over 1000% of non-treated control), except HCT116, SNU668 and KMS26 cells which their secretion was declined by EY-6. Data suggest the potential of EY-6 as a new type of immuno-chemotherapeutics inducing tumor-specific cell death. Further studies are planned to confirm the efficacy of EY-6 including in vivo study.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Gástricas
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Linhagem Celular
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Morte Celular
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Colo
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Interleucina-12
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Calreticulina
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Linhagem Celular Tumoral
Limite:
Humans
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2012
Tipo de documento:
Article