IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis
Annals of Dermatology
; : 468-473, 2011.
Article
em En
| WPRIM
| ID: wpr-155743
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31 has been implicated in the itching associated with AD. OBJECTIVE: We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters. METHODS: We recruited 55 AD patients, 34 with allergic type AD and 21 with non-allergic type AD, and 38 healthy, non-atopic controls. We checked the laboratory values, severity score, and serum IL-31 levels in all patients and controls, and IL-31 mRNA levels in lesion skin were measured in 13 subjects with AD and in four controls. RESULTS: AD patients displayed significantly higher levels of serum IL-31 that were associated with serum IgE, disease severity, and subjective itch intensity. In AD patients, IL-31 mRNA levels from the lesional skin samples also correlated with serum IL-31 level. CONCLUSION: IL-31 is likely one of the many mediators inducing inflammation and pruritus in AD. Although our limited sample size prevents us from making any definitive conclusions, our data demonstrate a strong correlation between IL-31 mRNA level and serum IL-31 protein level, which has never been reported before. Moreover, we found correlations between serum IL-31 level and serum IgE, eosinophil cationic protein, disease severity, and subject itch intensity in certain degrees in AD patients.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Prurido
/
Pele
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Imunoglobulina E
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RNA Mensageiro
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Tamanho da Amostra
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Proteína Catiônica de Eosinófilo
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Dermatite Atópica
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Inflamação
Limite:
Humans
Idioma:
En
Revista:
Annals of Dermatology
Ano de publicação:
2011
Tipo de documento:
Article