Ceftiaxone-Induced Neurotoxicity: Case Report, Pharmacokinetic Considerations, and Literature Review
Journal of Korean Medical Science
; : 1120-1123, 2012.
Article
em En
| WPRIM
| ID: wpr-157106
Biblioteca responsável:
WPRO
ABSTRACT
Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
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Base de dados:
WPRIM
Assunto principal:
Convulsões
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Trombose
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Infecções Urinárias
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Ceftriaxona
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Tomografia Computadorizada por Raios X
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Diálise Renal
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Urinálise
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Eletroencefalografia
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Insuficiência Renal Crônica
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Antibacterianos
Limite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2012
Tipo de documento:
Article