Arsenic Exposure and Prevalence of Diabetes Mellitus in Korean Adults
Journal of Korean Medical Science
; : 861-868, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-159654
Biblioteca responsável:
WPRO
ABSTRACT
It has been suggested that there is an association between environmental, low-level arsenic exposure and the risk of diabetes mellitus (DM), but little research has been conducted. Here, the glucose tolerance status and urinary creatinine adjusted total arsenic concentrations were analyzed in 3,602 subjects > or = 20 yr of age who were registered for the Korea National Health and Nutrition Examination Survey, 2008-2009. Various demographic parameters were associated with urinary arsenic concentrations. After adjusting for these variables, urinary arsenic concentrations in subjects with DM were significantly higher than those in subjects with normal glucose tolerance and those with impaired fasting glucose (P or = 193.4 microg/g creatinine, respectively, following multivariate adjustment. Furthermore, the urinary total arsenic concentration was inversely associated with the insulin secretion index, HOMA2 %B (beta = -0.033, P = 0.032). These findings suggest that arsenic exposure, possibly involving beta cell dysfunction, is associated with an increased risk of DM in the Korean population.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arsênio
/
Glicemia
/
Consumo de Bebidas Alcoólicas
/
Resistência à Insulina
/
Fumar
/
Razão de Chances
/
Inquéritos Nutricionais
/
Prevalência
/
Fatores de Risco
/
Povo Asiático
Tipo de estudo:
Estudo de etiologia
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2013
Tipo de documento:
Artigo