Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Korean Patients with Systemic Sclerosis
Journal of Korean Medical Science
; : 329-332, 2006.
Article
em En
| WPRIM
| ID: wpr-162120
Biblioteca responsável:
WPRO
ABSTRACT
To determine whether angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is associated with the development and clinical features of systemic sclerosis (SSc) in Korean, we studied seventy two Korean patients with SSc fulfilling the ACR preliminary classification criteria. The controls were 114 healthy, disease free Koreans. ACE I/D genotypes were determined by PCR method using oligonucleotides. Sixty eight patients (94.4%) were women and age at diagnosis was 43.5+/-12.6 yr old (mean+/-SD). Thirty nine patients (54.2%) had a diffuse type of SSc. There were no statistical differences in the frequencies of all ACE I/D genotypes and D allele between patients and controls, and neither between diffuse and limited types of SSc. ACE I/D gene polymorphism was not associated with the development of SSc in Korea. The investigation for the pathogenesis of SSc requires more studies about the role of other candidate genes such as endothelin, TGF-beta, nitric oxide, or angiotensin II receptor in addition to the ACE genes.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Escleroderma Sistêmico
/
DNA
/
Sequência de Bases
/
Estudos de Casos e Controles
/
Peptidil Dipeptidase A
/
Alelos
/
Frequência do Gene
/
Genótipo
/
Coreia (Geográfico)
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2006
Tipo de documento:
Article