Increasing the alpha 2, 6 Sialylation of Glycoproteins May Contribute to Metastatic Spread and Therapeutic Resistance in Colorectal Cancer
Gut and Liver
; : 629-641, 2013.
Article
em En
| WPRIM
| ID: wpr-162817
Biblioteca responsável:
WPRO
ABSTRACT
Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). In particular, increased ST6 Gal I (beta-galactoside alpha 2, 6 sialyltransferase) and subsequently elevated levels of cell-surface alpha 2, 6-linked sialic acids have been associated with metastasis and therapeutic failure in CRC. As many CRC patients experience metastasis to the liver or lung and fail to respond to curative therapies, intensive research efforts have sought to identify the molecular changes underlying CRC metastasis. ST6 Gal I has been shown to facilitate CRC metastasis, and we believe that additional investigations into the involvement of ST6 Gal I in CRC could facilitate the development of new diagnostic and therapeutic targets. This review summarizes how ST6 Gal I has been implicated in the altered expression of sialylated glycoproteins, which have been linked to CRC metastasis, radioresistance, and chemoresistance.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Tolerância a Radiação
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Ácidos Siálicos
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Sialiltransferases
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Glicoproteínas
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Neoplasias Colorretais
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Antígenos CD
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Resistencia a Medicamentos Antineoplásicos
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Receptores ErbB
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Neoplasias Hepáticas
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Neoplasias Pulmonares
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2013
Tipo de documento:
Article