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Protective effects of garlic juice against embryotoxicity of methylmercuric chloride administered to pregnant Fischer 344 rats
Yonsei Medical Journal ; : 483-489, 1999.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-164915
Biblioteca responsável: WPRO
ABSTRACT
In order to investigate the beneficial effects of 0.5 or 1.0 g/kg Korean garlic juice against the embryotoxicity of 20 mg/kg methylmercury chloride (MMC, CH3HgCl), pregnant Fisher 344 rats were simultaneously orally administered on day 7 of gestation. On day 20 of gestation the dams were laparotomized under ether anesthesia, and the fetuses were removed and examined for toxicity of methylmercury. Garlic juice depressed the toxicity in terms of some parameters. In the case of simultaneous treatment with 0.1 g/kg garlic juice and MMC, rates of increase were 17.5% in maternal body weight, 13.2% and 41.9% in fetal and litters' weight respectively, and 37.0% in fetal survival rate. Decreasing rates were 10.0% in maternal death rate, and 6.9% and 31.3% in pre- and post-implantation loss respectively. Decreasing rates of mercury levels in dams were 67.2% in liver, 57.6% in brain, 47.2% in kidney, 42.1% in spleen and 40.9% in blood. As well, decreasing rates of mercury level in fetuses were 54.9% in all body burden, 55.9% in liver, 46.7% in kidney and 37% in brain, respectively. The number of fetal ossification centers were reduced by 23.8% to 58.0% following simultaneous treatment with 1.0 g/kg garlic juice. These findings indicated that garlic juice effectively inhibited the embryotoxicity of methylmercury in pregnant Fischer 344 rats.
Assuntos

Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Obesidade Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Ratos Endogâmicos F344 / Peso Corporal / Distribuição Tecidual / Peso Fetal / Perda do Embrião / Estruturas Embrionárias / Alho / Animais / Compostos de Metilmercúrio Limite: Animais / Gravidez Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1999 Tipo de documento: Artigo
Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Obesidade Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Osteogênese / Ratos Endogâmicos F344 / Peso Corporal / Distribuição Tecidual / Peso Fetal / Perda do Embrião / Estruturas Embrionárias / Alho / Animais / Compostos de Metilmercúrio Limite: Animais / Gravidez Idioma: Inglês Revista: Yonsei Medical Journal Ano de publicação: 1999 Tipo de documento: Artigo
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