UDP-glucuronosyltransferase 1A1 Gene Polymorphism in Severe Neonatal Hyperbilirubinemia
Journal of the Korean Society of Neonatology
; : 46-52, 2007.
Article
em Ko
| WPRIM
| ID: wpr-16828
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
TATA box mutation/polymorphism in the promoter region of the bilirubin uridinediphosphoglucuronate glucuronosyltransferase 1A1 (UGT-1A1) gene is known to be an etiology of hyperbilirubinemia. This study examined if a TATA box mutation/polymorphism in UGT-1A1 gene promoter could be associated with the development of severe early neonatal jaundice in Korean infants.METHODS:
Thirty-nine neonatal jaundice patients and 40 controlled infants were analyzed for UGT-1A1 promoter genotypes by using DNA sequencing.RESULTS:
The homozygote for (TA)7TAA mutation was not found in this study. Comparison of the prevalence of UGT-1A1 promoter (TA)7TAA heterozygotes revealed no difference between the group with jaundice and the controlled group (15.4% vs. 10%). The peak bilirubin level was higher and the onset of jaundice was earlier in the jaundice group with (TA)7TAA heterozygote compared to the jaundice group without (TA)7TAA heterozygote (23.2+/-1.0 mg/dL vs. 19.7+/-2.4 mg/dL, P=0.004, 5.0+/-1.5 days vs. 8.3+/-4.1 days, P= 0.057).CONCLUSION:
The results of this study showed that TATA box polymorphism in UGT-1A1 gene promoter did not increase the prevalence of severe early neonatal jaundice in Korean infants.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Bilirrubina
/
Prevalência
/
TATA Box
/
Regiões Promotoras Genéticas
/
Glucuronosiltransferase
/
Análise de Sequência de DNA
/
Hiperbilirrubinemia Neonatal
/
Genótipo
/
Heterozigoto
/
Homozigoto
Tipo de estudo:
Prevalence_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
Ko
Revista:
Journal of the Korean Society of Neonatology
Ano de publicação:
2007
Tipo de documento:
Article