A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 251-256, 2011.
Article
em Ko
| WPRIM
| ID: wpr-169148
Biblioteca responsável:
WPRO
ABSTRACT
The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Protionamida
/
Valores de Referência
/
Rifampina
/
Tuberculose Pulmonar
/
Biópsia
/
Prevalência
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Doença Hepática Induzida por Substâncias e Drogas
/
Febre
/
Hepatite
Tipo de estudo:
Prevalence_studies
Limite:
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2011
Tipo de documento:
Article