Serological Immunity to Diphtheria among Korean Population / 감염
Korean Journal of Infectious Diseases
; : 278-283, 1998.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-170222
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Diphtheria epidemics in Russia have spread to all the other independent states of the former Soviet Union and East European countries around 1990s. One of the most important measures in preventing diphtheria is to maintain high levels of immunity in the population. We studied the diphtheria antibody levels of 1,086 participants to investigate herd immunity in Korea.METHODS:
The tested 1,086 serum specimens were collected from healthy individuals from September 1995 to March 1996. Diphtheria antitoxin titers were measured by a micro cell culture method using Vero cells. Antibody titer of 0.01 IU/ml to neutralize diphtheria toxin is an internationally accepted protective level.RESULTS:
We studied the diphtheria antitoxin titer levels of 1,086 cases consisting of 579 males and 507 females. The proportion of protective antitoxin level to diphtheria is 69.2%. Diphtheria antitoxin levels showed no significant difference between males and females. The highest seropositive rate was observed in the 5 to 9-year old age group(95.8%). The seropositivity rate declined with age. The lowest seropositive rate was observed in the 20~39 years of age, maximally 43.4 %. Over 40 years of age, the seropositive rates increased again.CONCLUSION:
The antibody titers in the Korean population declined from 95.8% to below 50% with age in the 1~39 year-old age group. To maintain the rate of population with protective antibodies to diphtheria, we recommend Td booster immunization to adults with low antitoxin titers and continuous survey for antitoxin titers.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
U.R.S.S.
/
Células Vero
/
Antitoxina Diftérica
/
Imunização Secundária
/
Federação Russa
/
Técnicas de Cultura de Células
/
Imunidade Coletiva
/
Difteria
/
Toxina Diftérica
/
Coreia (Geográfico)
Limite:
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
/
Europa
Idioma:
Coreano
Revista:
Korean Journal of Infectious Diseases
Ano de publicação:
1998
Tipo de documento:
Artigo