Perfusion MR Imaging in Gliomas: Comparison with Histologic Tumor Grade
Korean Journal of Radiology
; : 1-7, 2001.
Article
em En
| WPRIM
| ID: wpr-171865
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To determine the usefulness of perfusion MR imaging in assessing the histologic grade of cerebral gliomas. MATERIALS AND METHODS: In order to determine relative cerebral blood volume (rCBV), 22 patients with pathologically proven gliomas (9 glioblastomas, 9 anaplastic gliomas and 4 low-grade gliomas) underwent dynamic contrast-enhanced T2*-weighted and conventional T1- and T2-weighted imaging. rCBV maps were obtained by fitting a gamma-variate function to the contrast material concentration versus time curve. rCBV ratios between tumor and normal white matter (maximum rCBV of tumor / rCBV of contralateral white matter) were calcu-lated and compared between glioblastomas, anaplastic gliomas and low-grade gliomas. RESULTS: Mean rCBV ratios were 4.90'+/-1.01 for glioblastomas, 3.97'+/-0.56 for anaplastic gliomas and 1.75'+/-1.51 for low-grade gliomas, and were thus sig-nificantly different; p < .05 between glioblastomas and anaplastic gliomas, p <.05 between anaplastic gliomas and low-grade gliomas, p < .01 between glioblas-tomas and low-grade gliomas. The rCBV ratio cutoff value which permitted dis-crimination between high-grade (glioblastomas and anaplastic gliomas) and low-grade gliomas was 2.60, and the sensitivity and specificity of this value were 100% and 75%, respectively. CONCLUSION: Perfusion MR imaging is a useful and reliable technique for esti-mating the histologic grade of gliomas.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Astrocitoma
/
Encéfalo
/
Neoplasias Encefálicas
/
Imageamento por Ressonância Magnética
/
Circulação Cerebrovascular
/
Glioblastoma
/
Meios de Contraste
/
Gadolínio DTPA
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Korean Journal of Radiology
Ano de publicação:
2001
Tipo de documento:
Article