Feasibility of sentinel lymph node dissection using Tc-99m phytate in papillary thyroid carcinoma
Annals of Surgical Treatment and Research
; : 240-245, 2017.
Article
em En
| WPRIM
| ID: wpr-172617
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC). METHODS: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed. Preoperative single-photon emission-computed tomography (SPECT) and intraoperative gamma-probe were used for SLN detection during operation. RESULTS: Identification rate of SLNs was 70.6% (12 of 17) with SPECT, and 88.2% (15 of 17) with gamma-probe. Combined SPECT and gamma-probe had identification rates of 88.2% (15 of 17). Identification rates of SLNs in central LN compartments were 82.4% (14 of 17) and 41.2% (7 of 17) in lateral LN compartments. Overall sensitivity, specificity, positive predictive value, and negative predictive value of the results of SLN biopsy were 91.6%, 100%, 88.4%, and 100%, respectively. Eight patients (47.1%) had metastasis in SLNs; all patients had SLN metastasis in the central compartment and 2 patients had SLN metastasis in both the central and lateral compartments. CONCLUSION: Combined SPECT and gamma-probe could detect SLNs with an 88.2% identification rate in PTC. SLN biopsy using Tc-99m phytate is technically feasible. Further investigation is warranted for clinical application of Tc-99m phytate in PTC.
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Base de dados:
WPRIM
Assunto principal:
Ácido Fítico
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Glândula Tireoide
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Biópsia
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Mama
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Neoplasias da Glândula Tireoide
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Tomografia Computadorizada de Emissão de Fóton Único
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Colo do Útero
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Estudos Prospectivos
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Sensibilidade e Especificidade
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Neoplasias do Endométrio
Tipo de estudo:
Diagnostic_studies
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Observational_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2017
Tipo de documento:
Article