Median Effective Concentration (EC(50)) of Propofol for Insertion of Laryngeal Mask Airway and Laryngeal Tube in Children / 대한마취과학회지
Korean Journal of Anesthesiology
; : 330-334, 2006.
Article
em Ko
| WPRIM
| ID: wpr-17357
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The median effective concentration, EC(50), for the supraglottic airway (predicted plasma concentration equilibrated with the effect site at which supraglottic airway insertion is successful in 50% of patients) of propofol in children was not known. The aim of this study was to determine the EC(50) with a target-controlled infusion of propofol to insert a classic laryngeal mask airway (LMA) and laryngeal tube (LT) in pediatric patients. METHODS: Pediatric patients scheduled for urologic, orthopedic, or plastic surgery lasting less than 2 hr under general anesthesia were enrolled in this study. The patients were divided into two groups in a randomized, double blind manner. After applying a standard cardiorespiratory monitor, anesthesia was carried out with a target-controlled infusion (TCI) using the stelpump program. The initial target concentration of propofol was 5microgram/ml, and in accordance with Dixon's up-and-down, the propofol concentration for consecutive patients in each group was varied with increments or decrements of 0.2microgram/ml based on the previous patient insertion result. RESULTS: The EC(50) of propofol required to insert a LMA and LT was 5.5+/-0.2microgram/ml and 5.6+/-0.2microgram/ml, respectively. CONCLUSIONS: The EC50 of propofol is similar for LMA and LT.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Ortopedia
/
Plasma
/
Cirurgia Plástica
/
Propofol
/
Máscaras Laríngeas
/
Anestesia
/
Anestesia Geral
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2006
Tipo de documento:
Article