Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
Psychiatry Investigation
; : 56-61, 2013.
Article
em En
| WPRIM
| ID: wpr-17597
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: Both clinical and biological factors influence the course of depressive disorders. This study tested for associations between the brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the course of major depressive disorder (MDD). METHODS: Three hundred ten Korean subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 (G/A), which produces an amino acid substitution at codon 66 (Val66Met) of the gene for BDNF. Course of illness was evaluated both by chronicity of current episode (episode duration >24 months) and by the lifetime history of recurrences. RESULTS: Patients with the Met/Met BDNF genotype had a significantly higher rate of chronic depression than all others. There was a significant dose effect of the Met allele on chronicity. Compared with the Val/Val genotype, the relative risk of chronicity was 1.67 for the Val/Met genotype, and 2.58 for the Met/Met genotype. Lifetime history of recurrent episodes was not related to BDNF genotypes but was significantly associated with younger age of onset and with a history of depression in first degree relatives. CONCLUSION: BDNF genotyping may be informative for anticipating chronicity in major depression.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Códon
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Fatores Biológicos
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Idade de Início
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Fator Neurotrófico Derivado do Encéfalo
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Substituição de Aminoácidos
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Depressão
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Transtorno Depressivo Maior
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Transtorno Depressivo
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Alelos
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Genótipo
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2013
Tipo de documento:
Article