Chemoradiotherapy in squamous cell carcinoma of the anal canal: a single institution experience
Radiation Oncology Journal
; : 25-33, 2013.
Article
em En
| WPRIM
| ID: wpr-17609
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
We reviewed the treatment outcomes and prognostic factors for patients with anal canal carcinoma who were treated with curative intent chemoradiotherapy (CRT) at Severance Hospital from 2005 to 2011. MATERIALS ANDMETHODS:
Data for 38 eligible patients treated during this period were reviewed. All patients were treated with curative intent using radiotherapy (RT) with (n = 35) or without concomitant chemotherapy (n = 3). Among 35 patients who received CRT, most of the chemotherapeutic regimens were either 5-fluorouracil (5-FU) plus mitomycin C (23 patients) or 5-FU plus cisplatin (10 patients). Recurrence-free survival (RFS), colostomy-free survival (CFS), overall survival (OS), and locoregional control (LRC) rates were calculated using the Kaplan-Meier method and survival between subgroups were compared using the log-rank test. Cox's proportional hazard model was used for multivariate analysis.RESULTS:
Over a median follow-up period of 44 months (range, 11 to 96 months), 3-year RFS, CFS, OS, and LRC were 80%, 79%, 85%, and 92%, respectively. In multivariate analysis, tumor size >4 cm was an independent predicting factor for poorer RFS (hazard ratio [HR], 6.35; 95% confidence interval [CI], 1.42 to 28.5; p = 0.006) and CFS (HR, 6.25; 95% CI, 1.39-28.0; p = 0.017), while the presence of external iliac lymph node metastasis was an independent prognosticator for poorer OS (HR, 9.32; 95% CI, 1.24 to 70.3; p = 0.030). No treatment-related colostomies or deaths occurred during or after treatment.CONCLUSION:
Curative intent CRT resulted in excellent outcomes that were comparable to outcomes in previous randomized trials. No severe treatment-related toxicities were observed.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Canal Anal
/
Neoplasias do Ânus
/
Colostomia
/
Carcinoma de Células Escamosas
/
Modelos de Riscos Proporcionais
/
Análise Multivariada
/
Seguimentos
/
Cisplatino
/
Mitomicina
/
Quimiorradioterapia
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Radiation Oncology Journal
Ano de publicação:
2013
Tipo de documento:
Article