Expression and Mutational Analysis of c-kit in Ovarian Surface Epithelial Tumors
Journal of Korean Medical Science
; : 81-85, 2006.
Article
em En
| WPRIM
| ID: wpr-181113
Biblioteca responsável:
WPRO
ABSTRACT
Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas. Five cases of serous cystadenoma and 5 cases of mucinous cystadenoma were also included. In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. Only one case (1/13, 7.7%) of serous cystadenocarcinoma had positive staining. On mutational analysis, no mutation was identified at exon 11. However, two cases of borderline mucinous tumors and one case of mucinous cystadenocarcinoma had mutations at exon 17. In these cases, the immunohistochemistry also shows focal positive staining at epithelial component. Although, KIT protein expression showed higher incidence in mucinous tumors than serous tumors, they lack KIT-activating mutations in exon 11. Thus, ovarian surface epithelial tumors are unlikely to respond to imatinib mesylate.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Ovarianas
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DNA de Neoplasias
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Análise Mutacional de DNA
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Imuno-Histoquímica
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Regulação Neoplásica da Expressão Gênica
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Reação em Cadeia da Polimerase
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Cistadenoma Seroso
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Cistadenoma Mucinoso
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Cistadenocarcinoma Mucinoso
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Polimorfismo Conformacional de Fita Simples
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2006
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
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COREIA DO SUL
/
KR
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SOUTH KOREA