Sepsis Mortality in CIITA Deficient Mice is Associated with Excessive Release of High-mobility Group Box 1
Immune Network
; : 39-45, 2008.
Article
em En
| WPRIM
| ID: wpr-186559
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model.METHODS:
Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression.RESULTS:
Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1).CONCLUSION:
Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Recombinação Genética
/
Choque
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Proteínas Nucleares
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Linfócitos
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Punções
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Regulação para Baixo
/
Transativadores
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Taxa de Sobrevida
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Citocinas
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Terapia de Imunossupressão
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2008
Tipo de documento:
Article