Trends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011
Journal of Korean Medical Science
; : 67-73, 2013.
Article
em En
| WPRIM
| ID: wpr-188343
Biblioteca responsável:
WPRO
ABSTRACT
Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between pre-HAART and HAART era in Korea. Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART period (2002-2011). The patients were retrospectively classified according to the treatment period in which they were recruited. Although mortality rate per 100 person-year declined from 8.7 in pre-HAART to 4.9 in late-HAART period, the proportion of deaths within 3 months of initial visit to study hospital significantly increased from 15.9% in pre-HAART to 55.1% in late-HAART period (P < 0.001). Overall, 59% of deaths were attributable to AIDS-related conditions, and Pneumocystis pneumonia (PCP) was the most common cause of death (20.3%). The proportion of PCP as cause of death significantly increased from 8.7% in pre-HAART to 31.8% in late-HAART period (P < 0.001). Despite of significant improvement of survival, there was still a high risk of early death in patients presenting in HAART era, mainly due to late human immunodeficiency virus (HIV) diagnosis and late presentation to care.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pneumonia por Pneumocystis
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Infecções por HIV
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Estudos Retrospectivos
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Causas de Morte
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Síndrome da Imunodeficiência Adquirida
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Terapia Antirretroviral de Alta Atividade
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Estimativa de Kaplan-Meier
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República da Coreia
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2013
Tipo de documento:
Article