Clinical characteristics and serum N-terminal pro-brain natriuretic peptide as a diagnostic marker of Kawasaki disease in infants younger than 3 months of age / 소아과
Korean Journal of Pediatrics
; : 357-362, 2014.
Article
em En
| WPRIM
| ID: wpr-188733
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The incidence of Kawasaki disease (KD) is rare in young infants (less than 3 months of age), who present with only a few symptoms that fulfill the clinical diagnostic criteria. The diagnosis for KD can therefore be delayed, leading to a high risk of cardiac complications. We examined the clinical characteristics and measured the serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels of these patients for assessing its value in the early detection of KD. METHODS: We retrospectively reviewed the data of young infants diagnosed with KD from 2004 to 2012. The control group included 20 hospitalized febrile patients. Laboratory data, including NT-proBNP were obtained for each patient in both groups. RESULTS: Incomplete KD was observed in 21/24 patients (87.5%). The mean fever duration on admission was 1.36+/-1.0 days in the KD group. Common symptoms included erythema at the site of Bacille Calmette-Guerin inoculation (70.8%), skin rash (50.0%), changes of oropharyngeal mucosa (29.1%), and cervical lymphadenopathy (20.8%). The mean number of major diagnostic criteria fulfilled was 2.8+/-1.4. Five KD patients (20.8%) had only one symptom matching these criteria. The incidence of coronary artery complications was 12.5%. The mean serum NT-proBNP level in the acute phase, in the KD and control groups, were 4,159+/-3,714 pg/mL and 957+/-902 pg/mL, respectively, which decreased significantly in the convalescent phase. CONCLUSION: Incomplete KD was observed in 87.5% patients. Serum NT-proBNP might be a valuable biomarker for the early detection of KD in febrile infants aged <3 months.
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Base de dados:
WPRIM
Assunto principal:
Incidência
/
Estudos Retrospectivos
/
Vasos Coronários
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Peptídeo Natriurético Encefálico
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Diagnóstico
/
Eritema
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Exantema
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Febre
/
Doenças Linfáticas
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Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Humans
/
Infant
Idioma:
En
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2014
Tipo de documento:
Article