Efficacy of Topiramate in West Syndrome / 대한간질학회지

ABSTRACT

PURPOSE: The treatment of West syndrome is difficult since current antiepileptic drugs are rarely effective. The objective of this study is to evaluate the clinical efficacy of topiramate as add-on therapy in the refractory West Syndrome. METHODS: Nineteen children with refractory infantile spasms were included in this study. Topiramate was given as an initial dose of 25 mg per day in addition to the current antiepileptic drug (s). Dosage was increased by 25 mg every week until spasms were controlled, the maximal tolerable dose was reached, or the maximal dose of 25 mg/kg/day was achieved. RESULTS: Five (26.3%) subjects became seizure free and 7 (36.8%) achieved seizure frequency reduction more than 50%. No significant side effect of topiramate was noted. CONCLUSION: Topiramate could be a promising therapy in the treatment of refractory West syndrome.