Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells
Experimental & Molecular Medicine
; : 524-532, 2005.
Article
em En
| WPRIM
| ID: wpr-191499
Biblioteca responsável:
WPRO
ABSTRACT
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances, suggests that RANKL may have evolved as a part of the immunity to infection. As RANKL increases the survival and activity of dendritic cells, it may have similar effects on macrophages. To address this issue, we studied the effect of RANKL on various functions of macrophages using mouse bone marrow derived macrophages. RANKL enhanced the survival of macrophages and up-regulated the expression of CD86. RANKL-treated macrophages showed increased allogeneic T cell activation and phagocytic activity compared to control cells. In addition, RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-gamma, and iNOS. Collectively, RANKL augmented the activity of macrophages especially as antigen presenting cells, suggesting its new role in immune regulation.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fagocitose
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Glicoproteínas de Membrana
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Linfócitos T
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Proteínas de Transporte
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Antígenos de Histocompatibilidade Classe II
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Regulação para Cima
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Sobrevivência Celular
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Células Cultivadas
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Lipopolissacarídeos
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Citocinas
Limite:
Animals
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2005
Tipo de documento:
Article