Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
Toxicological Research
; : 157-164, 2013.
Article
em En
| WPRIM
| ID: wpr-193679
Biblioteca responsável:
WPRO
ABSTRACT
Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Encéfalo
/
Barreira Hematoencefálica
/
Xenobióticos
/
Incidência
/
Prevalência
/
Causas de Morte
/
Junções Íntimas
/
Metais Pesados
/
Acidente Vascular Cerebral
/
Células Endoteliais
Tipo de estudo:
Incidence_studies
/
Prevalence_studies
/
Prognostic_studies
Idioma:
En
Revista:
Toxicological Research
Ano de publicação:
2013
Tipo de documento:
Article