A YIDD Mutation in a Case of Recurrent Hepatitis B after Liver Transplantation Induced by an S-escape Mutant
Gut and Liver
; : 253-257, 2010.
Article
em En
| WPRIM
| ID: wpr-199721
Biblioteca responsável:
WPRO
ABSTRACT
A 47-year-old woman underwent orthotopic liver transplantation (OLT) for hepatitis B virus (HBV)-related end-stage liver cirrhosis. The patient received hepatitis B immunoglobulin prophylaxis after OLT. Despite the protective level of the serum anti-hepatitis-B surface antibody, HBV recurred at 22 months post-OLT and induced subacute hepatic failure. The pre-OLT HBV genome contained a complex mutation pattern in overlapping frame regions of the surface (S) and polymerase (P) genes, which is the same mutation pattern as seen in post-OLT HBV DNA. G145R and K141R mutations in the "a" determinant were detected only in the post-OLT sample. Clevudine (30 mg once daily) was administered for recurrent hepatitis B. Hepatitis B was reactivated with a flare-up, and a M204I mutation (YIDD mutant type) appeared with a higher viral load at 9 months after clevudine treatment. We report here a case of a YIDD mutation that developed in recurrent hepatitis B after OLT induced by an S-escape mutant.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Arabinofuranosiluracila
/
DNA
/
Imunoglobulinas
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Vírus da Hepatite B
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Transplante de Fígado
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Genoma
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Falência Hepática
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Carga Viral
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Hepatite
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Hepatite B
Limite:
Female
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Humans
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2010
Tipo de documento:
Article