Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats / 대한수의학회지
Korean Journal of Veterinary Research
; : 225-230, 2013.
Article
em En
| WPRIM
| ID: wpr-200775
Biblioteca responsável:
WPRO
ABSTRACT
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Arginase
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Óxido Nítrico Sintase Tipo II
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Coração
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Macrófagos
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Miocardite
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2013
Tipo de documento:
Article