Impact of Grade, Hormone Receptor, and HER-2 Status in Women with Breast Cancer on Response to Specific Chemotherapeutic Agents by in vitro Adenosine Triphosphate-based Chemotherapy Response Assay
Journal of Korean Medical Science
; : 1150-1157, 2009.
Article
em En
| WPRIM
| ID: wpr-203375
Biblioteca responsável:
WPRO
ABSTRACT
This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER- subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 status can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Neoplasias da Mama
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Ensaios de Seleção de Medicamentos Antitumorais
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Epirubicina
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Doxorrubicina
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Receptores de Progesterona
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Receptores de Estrogênio
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Trifosfato de Adenosina
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Paclitaxel
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Receptor ErbB-2
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Fluoruracila
Limite:
Adult
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Aged
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Female
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Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2009
Tipo de documento:
Article