Hemophagocytic Lymphohistiocytosis after Lung Transplantation / 대한중환자의학회지
Korean Journal of Critical Care Medicine
; : 38-41, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-204511
Biblioteca responsável:
WPRO
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal complication after solid organ transplantation. Acquired forms of HLH are described in association with severe sepsis, autoimmune disorders, malignancy, immune-compromised states, infections, and solid organ transplantation. We experienced a case of hemophagocytic lymphohistiocytosis after bilateral lung transplantation. Leukopenia, thrombocytopenia, and hyperbilirubinemia were noted and became aggravated 50 days after transplantation. Diagnosis of HLH was based on clinical and laboratory findings of splenomegaly, cytopenia, elevated ferritin, elevated interleukin-2 receptor, and hemophagocytosis in bone marrow. Other features such as elevated bilirubin, lactate dehydrogenase, and D-dimer which can be present in HLH were also noted. The patient was immediately treated with etoposide and dexamethasone. Despite aggressive therapy, the patient deteriorated and died. Awareness of the diagnostic criteria of HLH after lung transplantation is important for clinicians.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esplenomegalia
/
Trombocitopenia
/
Bilirrubina
/
Medula Óssea
/
Dexametasona
/
Transplante de Órgãos
/
Transplante de Pulmão
/
Interleucina-2
/
Sepse
/
Transplantes
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Critical Care Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo