Thrombotic thrombocytopenic purpura in three pregnancies / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 434-442, 2010.
Article
em Ko
| WPRIM
| ID: wpr-208971
Biblioteca responsável:
WPRO
ABSTRACT
Thromobotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction, is severe multisystem disorder. TTP-HUS occurs predominantly in the reproductive aged-women, associated with poor prognosis. Although the morbidity and mortality have been significantly decreased by using plasma exchange therapy, refractory TTP-HUS remains a tremendous problem. It is crucial to differentiate other microangiopathic hemolytic anemia disease with a confusing presentation and to perform the immediate plasmapheresis. We have experienced three cases, which were initially diagnosed as HELLP syndrome or immune thrombocytopenic purpura. Despite of aggressive plasmapheresis, two women died. We present these cases with a review of the literature on pregnancy-associated thrombotic microangiopathy, including ADAMTS-13 activity assay as a new diagnostic test.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Troca Plasmática
/
Pré-Eclâmpsia
/
Complicações na Gravidez
/
Prognóstico
/
Púrpura Trombocitopênica Trombótica
/
Trombocitopenia
/
Sistema Nervoso Central
/
Plasmaferese
/
Púrpura Trombocitopênica Idiopática
/
Síndrome HELLP
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2010
Tipo de documento:
Article