Bone Regeneration from Adipose Stem Cells

ABSTRACT

Reconstruction of large bone defect poses a great challenge to an orthopedic surgeon. Recent advancement in stem cell research ushered the treatment of bone defect with tissue-engineered bone into near-possibility. While adipose stem cells (ASCs) are the most available cell sources for tissue regeneration, their low osteogenic potential is a disadvantage. Several strategies have been developed to enhance the osteogenic differentiation of ASCs. In this review, we summarized literatures and our experience on the technology to promote osteogenesis from ASCs.