The Serial Change of Cerebral Hemodynamics by Vascular Territory after Extracranial-Intracranial Bypass Surgery in Patients with Atherosclerosis of Cerebral Arteries / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
; : 8-16, 2008.
Article
em Ko
| WPRIM
| ID: wpr-223061
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To assess the effect of extracranial-intracranial (EC-IC) bypass surgery on hemodynamic improvement, we evaluated serial regional cerebral hemodynamic change of the middle cerebral artery (MCA) in symptomatic patients with atherosclerotic occlusion of the internal carotid artery (ICA) or MCA using (99m)Tc-ECD acetazolamide stress brain perfusion SPECT (Acetazolamide SPECT). MATERIAL ANDMETHODS:
The patients who had suffered a recent stroke with atherosclerotic ICA or MCA occlusion underwent EC-IC bypass surgery and Acetazolamide SPECT at 1 week before and three to six months after surgery. For image analysis, attenuation corrected images were spatially normalized to SPECT templates with SPM2. Anatomical automated labeling was applied to calculate mean counts of each Volume-Of-Interest (VOI). Seven VOIs of bilateral frontal, parietal, temporal regions of the MCA territory and the ipsilateral cerebellum were defined. Using mean counts of 7 VOIs, cerebral perfusion index and perfusion reserve index were calculated.RESULTS:
Seventeen patients (MF=125, mean age 53+/-2yr) were finally included in the analysis. The cerebral blood flow of the parietal region increased at 1 week (p=0.003) and decreased to the preoperative level at 3-6 months (p=0.003). The cerebrovascular reserve of the frontal and parietal regions increased significantly at 1 week after surgery (p<0.01) and improved further at 3-6 months.CONCLUSION:
Cerebrovascular reserve of the MCA territory was significantly improved at early postoperative period after EC-IC bypass and kept improved state during long-term follow-up, although cerebral blood flow did not significantly improved. Therefore, cerebrovascular reserve may be a good indicator of postoperative hemodynamic improvement resulted from bypass effect.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Perfusão
/
Período Pós-Operatório
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Encéfalo
/
Artéria Carótida Interna
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Tomografia Computadorizada de Emissão de Fóton Único
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Cerebelo
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Artérias Cerebrais
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Revascularização Cerebral
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Seguimentos
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Artéria Cerebral Média
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Nuclear Medicine and Molecular Imaging
Ano de publicação:
2008
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
COREIA DO SUL
/
KR
/
SOUTH KOREA