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Outcome of Gamma Knife Thalamotomy in Patients with an Intractable Tremor
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-223801
Biblioteca responsável: WPRO
ABSTRACT

OBJECTIVE:

Tremor is a common movement disorder that interferes with daily living. Since the medication for tremor has some limitations, surgical intervention is needed in many patients. In certain patients who cannot undergo aggressive surgical intervention, Gamma Knife thalamotomy (GKT) is a safe and effective alternative.

METHODS:

From June 2012 to August 2013, 7 patients with an intractable tremor underwent GKT. Four of these 7 patients had medical comorbidities, and 3 patients refused to undergo traditional surgery. Each patient was evaluated with the modified Fahn-Tolosa-Marin tremor rating scale (TRS) along with analysis of handwriting samples. All of the patients underwent GKT with a maximal dose of 130 Gy to the left ventralis intermedius (VIM) nucleus of the thalamus. Follow-up brain MRI was performed after 3 to 8 months of GKT, and evaluation with the TRS was also performed.

RESULTS:

Six patients showed objective improvement in the TRS score. Excluding one patient who demonstrated tremor progression, there was 28.9% improvement in the TRS score. However, five patients showed subjective improvement in their symptoms. On comparing the TRS scores between follow-up periods of more and less than 4 months, the follow-up TRS score at more than 4 months of GKT was significantly improved compared to that at less than 4 months of GKT. Follow-up MRI showed radiosurgical changes in 5 patients.

CONCLUSION:

GKT with a maximal dose of 130 Gy to the VIM is a safe procedure that can replace other surgical procedures.
Assuntos

Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Tálamo / Tremor / Encéfalo / Imageamento por Ressonância Magnética / Comorbidade / Seguimentos / Escrita Manual / Transtornos dos Movimentos Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Korean Neurosurgical Society Ano de publicação: 2015 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Tálamo / Tremor / Encéfalo / Imageamento por Ressonância Magnética / Comorbidade / Seguimentos / Escrita Manual / Transtornos dos Movimentos Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Journal of Korean Neurosurgical Society Ano de publicação: 2015 Tipo de documento: Artigo
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